Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction

Lucy A Bartho; Daniel R McKeating; Susan P Walker; Brunda Nijagal; Teresa M MacDonald; Natasha Pritchard; Natalie J Hannan; Anthony V Perkins; Stephen Tong; Tu’uhevaha J Kaitu’u-Lino

Journal article

Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction

Lucy A Bartho, Daniel R McKeating, Susan P Walker, Brunda Nijagal, Teresa M MacDonald, Natasha Pritchard, Natalie J Hannan, Anthony V Perkins, Stephen Tong, Tu’uhevaha J Kaitu’u-Lino

Scientific Reports | Nature Portfolio | Published : 2024

DOI: 10.1038/s41598-024-65947-9

Download PDF

Abstract

Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into the health and development of both mother and fetus throughout pregnancy. This study assessed metabolic profiles in the maternal circulation prior to and at the time of diagnosis of preeclampsia and fetal growth restriction. Maternal plasma samples were collected from two independent cohorts: (1) Established disease cohort: 50 participants diagnosed with early-onset preeclampsia (< 34 weeks' gestation), 14 with early-onset fetal growth restriction, and 25 gestation-matched controls. (2) Prospective cohort, collected at 36 weeks' gestation be..

View full abstract

University of Melbourne Researchers

Lucy Bartho Author

Susan Walker Author

Brunda Nijagal Author

Teresa MacDonald Author

Related Projects (4)

IMPROVING THE PREDICTION AND DETECTION OF CONTRIBUTORS TO TERM STILLBIRTH

Stillbirths are a global human tragedy, with 1 in 130 of all pregnancies in Australia ending in stillbirth. We propose to use ultrasound and..

TRANSLATING NEW THERAPEUTICS AND DIAGNOSTICS FOR MAJOR PREGNANCY COMPLICATIONS

My research is focussed on tackling major complications of pregnancy that are a threat to the lives of both mother’s and babies. We are deve..

NEW DIAGNOSTICS TO PREDICT PREECLAMPSIA AND FETAL GROWTH RESTRICTION

Preeclampsia and fetal growth restriction are two of the most serious complications of pregnancy, claiming the lives of tens of thousands of..

Developing a Screening Test to Identify Women at Risk of Preeclampsia

Preeclampsia is a serious complication of pregnancy for which there is currently no cure and no way to accurately predict women at risk. Usi..

Grants

Awarded by Department of Health | National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council

Funding Acknowledgements

We thank Alison Abboud, Danica Idzes and Valerie Kyritsis for recruitment and collection of blood samples. We also thank Gabrielle Pell, Rachel Murdoch, Genevieve Christophers, for their assistance in recruiting participants and blood samples. We also wish to thank the pathology, health information services, and antenatal clinic staff at the Mercy Hospital for Women for their assistance in conducting this research.